Madonna's brother says her split from husband Guy Ritchie was brought about by the singer's devotion to Kabbalah.
Christopher Ciccone - who recently penned a tell-all book on his big sis - also says there is no chance of the star couple getting back together.
The gay interior decorator told German newspaper Bild: "The Kabbalah sect, to which Madonna is completely devoted, played a large role in this marriage.
"It was based on it. And that is not enough on which to base a marriage and it couldn't have survived.
"As for a reconciliation - I really don't think so. With two such ambitious and headstrong personalities, it would just be too hard."
Christopher, who had a big falling out with Guy, added: "He is not the easiest guy to get along with. We don't really see eye to eye.
"I really have no idea what my sister loved about him. I suppose I could have tried to stop her.
"But I always wanted to welcome those people whom Madonna let into her life. Whether it was WARREN BEATTY, SEAN PENN or CARLOS LEON.
"They were and are good friends of mine. Guy was the first who couldn't bear how close Madonna and I were."